Goals: The major goal of this proposal is to recruit a superb and diverse group of health science scholars early in their academic careers to enable them to conduct important research, and to facilitate their long-term retention for significant contributions as researchers and leaders with a focus in the research of benign urologic diseases.
Roles: Principal Investigator
NIH/ HICHHD R01HD074579 (Baskin UCSF site director)
Short-term outcomes of interventions for reproductive dysfunction
Goals: Multicenter prospective study to Determine outcomes of patients with disorders of sex development.
NIH/NIDDK – R01 DK58105-6 (Baskin) (Continuation)
Hypospadias Differentiation and Endocrine Disruptors
Goals: The main goal of this proposal is to investigate the mechanism of normal and abnormal urethral development focusing on a new alternative etiology of hypospadias.
During development tubularization of the urethra requires, formation of a urethral plate, fusion of the urethral folds, formation of an epithelial seam and subsequent seam removal.
Goals: The major goal of this proposal is to examine the role of estrogens and androgens in normal masculine and feminine development of the external genitalia of the spotted hyena
Roles: Subcontract PI
R01 ES16863 (Subaward PI: Baskin)
The Infant Development and Environment Study (TIDES)
Goals: The major goal of this proposal is to confirm the hypothesis that male anogenital distance (AGD) at birth is inversely related to the concentration of one or more metabolites of DEHP and DBP, separately or in combination, in first trimester urine samples, to develop a simple, reproducible method for measuring AGD in a clinical setting, and determine standardized percentiles for these in male newborns, and test the hypothesis that a shortened AGD is a long-lasting marker of altered genital tract development in males, by comparing AGD percentiles at birth, 6 and 12 months.
U10 HD41669 (Harrison)
COOP Multicenter Trial of Fetal Myelomeningocele Repair
Goals: The main goal of this proposal is to determine whether intrauterine repair of fetal myelomeningocele at 190 to 256 weeks gestation improves outcome, as measured by 1) death or the need for ventricular decompressive shunting by one year of life, and 2) a composite neurologic function score at 30 months corrected age.
Roles: Co-Investigator to assess long term bladder and bowel control.